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Apathetic symptoms and white matter integrity after traumatic brain injury

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dc.contributor.authorNavarro-Main, Blanca
dc.contributor.authorCastaño León, Ana María
dc.contributor.authorHilario Barrio, Amaya
dc.contributor.authorLagares, A
dc.contributor.authorAlbarrán Periáñez, José David
dc.contributor.authorRíos Lago, Marcos
dc.contributor.authorInertia Group Collaborators
dc.contributor.funderFundación Mapfre, Beca Ignacio Larramendi
dc.date.accessioned2025-12-19T14:33:22Z
dc.date.available2025-12-19T14:33:22Z
dc.date.issued2021-08-06
dc.descriptionThis is an Accepted Manuscript of an article published by Taylor and Francis Group in "Brain Injury, 35(9), 1043–1053", available at: https://doi.org/10.1080/02699052.2021.1953145
dc.descriptionEste es el manuscrito aceptado del artículo publicado por Taylor and Francis Group en "Brain Injury, 35(9), 1043–1053", disponible en línea: https://doi.org/10.1080/02699052.2021.1953145
dc.description.abstractPrimary objective The aim of the study was twofold. First, to study the relationship among apathy in the long term, initial clinical measures, and standard outcome scores after traumatic brain injury (TBI). Second, to describe white matter integrity correlates of apathy symptoms. Research Design Correlational study. Methods and Procedures: Correlation and Bayesian networks analyses were performed in a sample of 40 patients with moderate to severe TBI in order to identify the relationship among clinical variables, functionality, and apathy. A diffusion tensor imaging study was developed in 25 participants to describe correlations between fractional anisotropy (FA) measures and apathetic symptoms. Main outcomes and results Correlation analysis revealed associations between pairs of variables as apathy in the long term and functional score at discharge from hospital. Bayesian network illustrated the relevant role of axonal injury mediating the relationship between apathy and initial clinical variables. FA in the superior longitudinal fasciculus, the inferior longitudinal fasciculus, and the internal capsule were negatively correlated with apathy measures. Widespread brain areas showed positive correlations between FA and apathy. Conclusions These results highlight the relevance of white matter integrity measures in initial assessment after TBI and its relationship with apathetic manifestations in the chronic phase.en
dc.description.provenanceMade available in DSpace on 2025-12-19T14:33:22Z (GMT). No. of bitstreams: 1 Rios_Lago_Marcos_Apathetic_symptoms_and_white_MARCOS RIOS LAGO.pdf: 1695046 bytes, checksum: 71367b6370b116f07fde0c24e4603ca8 (MD5) Previous issue date: 2021-08-06en
dc.description.versionversión final
dc.identifier.citationNavarro-Main, B., Castaño-León, A., Hilario, A., Lagares, A., Rubio, G., Periañez, J., … INERTIA group collaborators. (2021). Apathetic symptoms and white matter integrity after traumatic brain injury. Brain Injury, 35(9), 1043–1053. https://doi.org/10.1080/02699052.2021.1953145
dc.identifier.doihttps://doi.org/10.1080/02699052.2021.1953145
dc.identifier.eissn1362-301X
dc.identifier.issn0269-9052
dc.identifier.urihttps://hdl.handle.net/20.500.14468/31235
dc.journal.issue9
dc.journal.titleBrain Injury
dc.journal.volume35
dc.language.isoen
dc.page.final1053
dc.page.initial1043
dc.publisherTaylor & Francis
dc.relation.centerFacultad de Psicología
dc.relation.departmentPsicología Básica II
dc.relation.researchgroupEstudios de Criminología y Política Criminal (GECYP)
dc.relation.researchgroupGrupo de Investigación en Neurociencia cognitiva y Neuroimagen (GINN)
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject3213.08 Neurocirugía
dc.subject.keywordstraumatic brain injuryen
dc.subject.keywordswhite matteren
dc.subject.keywordsDTen
dc.subject.keywordsBayesian networksen
dc.subject.keywordsapathyen
dc.titleApathetic symptoms and white matter integrity after traumatic brain injuryen
dc.typeartículoes
dc.typejournal articleen
dspace.entity.typePublication
relation.isAuthorOfPublicationaf57252a-e8fc-470d-b074-180e993a33c4
relation.isAuthorOfPublication.latestForDiscoveryaf57252a-e8fc-470d-b074-180e993a33c4
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