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Involvement of virus infections and antiviral agents in schizophrenia

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dc.contributor.authorBorrego Ruiz, Alejandro
dc.contributor.authorBorrego, Juan J.
dc.date.accessioned2025-07-15T12:39:30Z
dc.date.available2025-07-15T12:39:30Z
dc.date.issued2025-03-10
dc.descriptionThe registered version of this article, first published in “Psychological Medicine, 55, (2025) e73, ", is available online at the publisher's website: Cambridge University Press, https://doi.org/10.1017/S0033291725000467 La versión registrada de este artículo, publicado por primera vez en “Psychological Medicine, 55 (2025), e73, ", está disponible en línea en el sitio web del editor: Cambridge University Press, https://doi.org/10.1017/S0033291725000467
dc.description.abstractBackground. Schizophrenia is a chronic and complex mental disorder resulting from interactions between cumulative and synergistic genetic and environmental factors. Viral infection during the prenatal stage constitutes one of the most relevant risk factors for the development of schizophrenia later in adulthood. Methods. A narrative review was conducted to explore the link between viral infections and schizophrenia, as well as the neuropsychiatric effects of antiviral drugs, particularly in the context of this specific mental condition. Literature searches were performed using the PubMed, Scopus, and Web of Science databases. Results. Several viral infections, such as herpesviruses, influenza virus, Borna disease virus, and coronaviruses, can directly or indirectly disrupt normal fetal brain development by modifying gene expression in the maternal immune system, thereby contributing to the pathophysiological symptoms of schizophrenia. In addition, neuropsychiatric effects caused by antiviral drugs are frequent and represent significant adverse outcomes for viral treatment. Conclusions. Epidemiological evidence suggests a potential relationship between viruses and schizophrenia. Increases in inflammatory cytokine levels and changes in the expression of key genes observed in several viral infections may constitute potential links between these viral infections and schizophrenia. Furthermore, antivirals may affect the central nervous system, although for most drugs, their mechanisms of action are still unclear, and a strong relationship between antivirals and schizophrenia has not yet been established.en
dc.description.provenanceMade available in DSpace on 2025-07-15T12:39:30Z (GMT). No. of bitstreams: 1 Borrego_Ruiz_Alejandro_Virus_Schizophrenia_ALEJANDRO BORREGO RU.pdf: 942640 bytes, checksum: dae860b1e35f27e5855f2e6563f2a63d (MD5) Previous issue date: 2025-03-10en
dc.description.versionversión publicada
dc.identifier.citationBorrego-Ruiz, A., & Borrego, J. J. (2025). Involvement of virus infections and antiviral agents in schizophrenia. Psychological Medicine, 55, e73. (2025). https://doi.org/10.1017/S0033291725000467
dc.identifier.doihttps://doi.org/10.1017/S0033291725000467
dc.identifier.issn0033-2917, eISSN 1469-8978
dc.identifier.urihttps://hdl.handle.net/20.500.14468/29495
dc.journal.titlePsychological Medicine
dc.journal.volume55
dc.language.isoen
dc.publisherCambridge University Press
dc.relation.centerFacultad de Psicología
dc.relation.departmentPsicología Social y de las Organizaciones
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject6114 Psicología social
dc.subject2414 Microbiología
dc.subject.keywordsantiviral agentsen
dc.subject.keywordsBorna disease virusen
dc.subject.keywordscoronavirusesen
dc.subject.keywordsherpesvirusesen
dc.subject.keywordsinfluenza virusen
dc.subject.keywordsschizophreniaen
dc.subject.keywordsviral infectionen
dc.titleInvolvement of virus infections and antiviral agents in schizophreniaen
dc.typejournal articleen
dspace.entity.typePublication
relation.isAuthorOfPublication4056d333-e1b2-4759-8b5a-af6f4e202fd8
relation.isAuthorOfPublication.latestForDiscovery4056d333-e1b2-4759-8b5a-af6f4e202fd8
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