Cargando...
Fecha
2025-03-10
Derechos de acceso
info:eu-repo/semantics/openAccess
Título de la revista
ISSN de la revista
Título del volumen
Editorial
Cambridge University Press
Citas
Resumen
Background. Schizophrenia is a chronic and complex mental disorder resulting from interactions between cumulative and synergistic genetic and environmental factors. Viral infection during the prenatal stage constitutes one of the most relevant risk factors for the development of schizophrenia later in adulthood.
Methods. A narrative review was conducted to explore the link between viral infections and schizophrenia, as well as the neuropsychiatric effects of antiviral drugs, particularly in the context of this specific mental condition. Literature searches were performed using the PubMed, Scopus, and Web of Science databases.
Results. Several viral infections, such as herpesviruses, influenza virus, Borna disease virus, and coronaviruses, can directly or indirectly disrupt normal fetal brain development by modifying gene expression in the maternal immune system, thereby contributing to the pathophysiological symptoms of schizophrenia. In addition, neuropsychiatric effects caused by antiviral drugs are frequent and represent significant adverse outcomes for viral treatment.
Conclusions. Epidemiological evidence suggests a potential relationship between viruses and schizophrenia. Increases in inflammatory cytokine levels and changes in the expression of key genes observed in several viral infections may constitute potential links between these viral infections and schizophrenia. Furthermore, antivirals may affect the central nervous system, although for most drugs, their mechanisms of action are still unclear, and a strong relationship between antivirals and schizophrenia has not yet been established.
Descripción
The registered version of this article, first published in “Psychological Medicine, 55, (2025) e73, ", is available online at the publisher's website: Cambridge University Press, https://doi.org/10.1017/S0033291725000467
La versión registrada de este artículo, publicado por primera vez en “Psychological Medicine, 55 (2025), e73, ", está disponible en línea en el sitio web del editor: Cambridge University Press, https://doi.org/10.1017/S0033291725000467
Categorías UNESCO
Palabras clave
antiviral agents, Borna disease virus, coronaviruses, herpesviruses, influenza virus, schizophrenia, viral infection
Citación
Borrego-Ruiz, A., & Borrego, J. J. (2025). Involvement of virus infections and antiviral agents in schizophrenia. Psychological Medicine, 55, e73. (2025). https://doi.org/10.1017/S0033291725000467
Centro
Facultad de Psicología
Departamento
Psicología Social y de las Organizaciones