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New salty extraction of polar analytes technique and oil-based cleanup (SExPA-Oc) for the determination of nereistoxins in vegetable samples with HILIC-MS/MS

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dc.contributor.authorPérez Figueroa, J. L.
dc.contributor.authorFernández Hernando, Pilar
dc.contributor.authorGarcía Mayor, M Asunción
dc.contributor.authorGarcinuño Martínez, Rosa Mª
dc.contributor.funderInstituto de Salud Carlos III
dc.contributor.funderUniversidad Nacional de Educación a Distancia (UNED)
dc.contributor.funderIMIENS
dc.date.accessioned2026-01-16T09:13:20Z
dc.date.available2026-01-16T09:13:20Z
dc.date.issued2025-10-07
dc.descriptionThe registered version of this article, first published in “Food Chemistry, 496, 146668", is available online at the publisher's website: https://doi.org/10.1016/j.foodchem.2025.146668
dc.descriptionLa versión registrada de este artículo, publicado por primera vez en “Food Chemistry, 496, 146668", está disponible en línea en el sitio web del editor: https://doi.org/10.1016/j.foodchem.2025.146668
dc.description.abstractNereistoxins are polar, unstable insecticides that present significant analytical challenges in agricultural products due to rapid degradation, limiting reliable monitoring in food safety programs. This study was carried out to address these challenges by developing a stable, efficient, and cost-effective method for the extraction and quantification of nereistoxins (cartap, nereistoxin, thiocyclam, thiosultap) in tomatoes, avocados, and olive oil. The novel SExPA-Oc (salty extraction of polar analytes–oil cleanup) method uses a salt-assisted liquid-liquid partition combined with an olive oil cleanup step, eliminating the need for expensive sorbents while improving analyte stability. Analysis by Hydrophilic Interaction Liquid Chromatography coupled with tandem mass spectrometry (HILIC-MS) achieved a linear range of 3–800 μg/kg and recoveries exceeding 70 % in most matrices, with limits of quantification meeting regulatory standards. This strategy provides a robust, environmentally friendly solution for nereistoxin analysis, addressing gaps in food safety monitoring and broader applicability to other polar, unstable compounds.en
dc.description.provenanceMade available in DSpace on 2026-01-16T09:13:20Z (GMT). No. of bitstreams: 1 Paper publicado_Food Chemistry_2025_ROSA M. GARCINUNO MA.pdf: 2725725 bytes, checksum: 78b609a95658d74117b6ccee3c3a3967 (MD5) Previous issue date: 2025-10-07en
dc.description.sponsorshipThis work was supported by IMIENS (Joint Research Institute, Instituto de Salud Carlos III–UNED, Madrid, Spain) (IMIENS-2024-004-PIC), the National University of Distance Education (50ANIV-GARCIN-UNED 50; 2025/00150/001) and a special acknowledgement to the Company Granada La Palma S.C.A. for providing access to their laboratory facilities and contributing necessary resources for the development of this project.
dc.description.versionversión publicada
dc.identifier.citationPérez-Figueroa, Fernández-Hernando, Mayor, M. A. G., & Garcinuño. (2025). New salty extraction of polar analytes technique and oil-based cleanup (SExPA-Oc) for the determination of nereistoxins in vegetable samples with HILIC-MS/MS. Food Chemistry, 496. https://doi.org/10.1016/j.foodchem.2025.146668
dc.identifier.doihttps://doi.org/10.1016/j.foodchem.2025.146668
dc.identifier.issn0308-8146
dc.identifier.urihttps://hdl.handle.net/20.500.14468/31433
dc.journal.titleFood Chemistry
dc.journal.volume496
dc.language.isoen
dc.publisherElsevier
dc.relation.centerFacultad de Ciencias
dc.relation.departmentCiencias Analíticas
dc.relation.projectidinfo:eu-repo/grantAgreement/IMIENS//IMIENS-2024-004-PIC
dc.relation.projectidinfo:eu-repo/grantAgreement/UNED//50ANIV-GARCIN-UNED 50; 2025/00150/001
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject2301 Química analítica
dc.subject.keywordsAgrochemical residuesen
dc.subject.keywordsFood safety monitoringen
dc.subject.keywordsLiquid-liquid extractionen
dc.subject.keywordsOlive oil cleanupen
dc.titleNew salty extraction of polar analytes technique and oil-based cleanup (SExPA-Oc) for the determination of nereistoxins in vegetable samples with HILIC-MS/MSen
dc.typeartículoes
dc.typejournal articleen
dspace.entity.typePublication
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