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Mutational randomness as conditional independence and the experimental vindication of mutational Lamarckism

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dc.contributor.authorRazeto Barry, Pablo
dc.contributor.authorVecchi, Davide
dc.contributor.funderFundação para a Ciência e a Tecnologia (Portugal)
dc.date.accessioned2026-02-24T09:11:45Z
dc.date.available2026-02-24T09:11:45Z
dc.date.issued2016-01-29
dc.descriptionThis is the Accepted Manuscript of an article published by WILEY in "Biological Reviews 92, 2017", available online: https://doi.org/10.1111/brv.12249
dc.descriptionEste es el manuscrito aceptado de un artículo publicado por WILEY en " Biological Reviews 92, 2017", disponible en línea: https://doi.org/10.1111/brv.12249
dc.description.abstractThe Modern Synthesis enshrined natural selection as the driver of adaptive evolution mainly by eliminating competing explanations. One of the eliminated competitors was Lamarckism, particularly ‘mutational Lamarckism’, a hypothesis according to which mutations may be directed towards producing phenotypes that improve the performance of the organism in a particular environment. Contrary to this hypothesis, the Modern Synthesis' view claims that mutations are ‘random’, even though the precise meaning of the term was never formally explicated. Current evidence seemingly in favour of the existence of legitimate cases of mutational Lamarckism has revitalized interest to seek a clarification of the meaning of the term ‘random’ in this context. Herein we analyse previous definitions of random mutations and show that they are deficient in three ways: either they are too wide, or too narrow, or dyadic. We argue that the linguistic expression ‘random mutation’ refers to a triadic rather than a dyadic relationship, propose a new, formal and precise definition based on the probabilistic concept of conditional independence, and finally provide examples of its application. One important consequence of our analysis is that the genomic specificity of the mutational process is not a necessary condition for the existence of mutational Lamarckism.en
dc.description.provenanceMade available in DSpace on 2026-02-24T09:11:45Z (GMT). No. of bitstreams: 1 Razeto y Vecchi 2017_AAM_DAVIDE VECCHI.pdf: 328001 bytes, checksum: 107036032115055104403e37510f8a90 (MD5) Previous issue date: 2016-01-29en
dc.description.versionversión final
dc.identifier.citationRazeto-Barry, P., Vecchi, D. 2017. Mutational randomness as conditional independence and the experimental vindication of mutational Lamarckism. Biological Reviews 92(2):673-683. DOI: 10.1111/BRV.12249
dc.identifier.doihttps://doi.org/10.1111/brv.12249
dc.identifier.eissn1469-185X
dc.identifier.issn1464-7931
dc.identifier.urihttps://hdl.handle.net/20.500.14468/31914
dc.journal.issue2
dc.journal.titleBiological Reviews
dc.journal.volume92
dc.language.isoen
dc.page.final683
dc.page.initial673
dc.publisherWILEY
dc.relation.centerFacultad de Filosofía
dc.relation.departmentLógica, Historia y Filosofía de la Ciencia
dc.relation.projectidinfo:eu-repo/grantAgreement/FCT//SFRH/BPD/99879/2014/Towards an heteroplastic view of biology (Hacia una visión heteroplástica de la biología)
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject72 Filosofía
dc.subject11 Lógica
dc.subject.keywordsrandomnessen
dc.subject.keywordsLamarcken
dc.subject.keywordsdirected mutationen
dc.subject.keywordsadaptive mutationen
dc.subject.keywordsconditional independenceen
dc.titleMutational randomness as conditional independence and the experimental vindication of mutational Lamarckismen
dc.typeartículoes
dc.typejournal articleen
dspace.entity.typePublication
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relation.isAuthorOfPublication.latestForDiscovery4cfbacde-6c78-4f6b-80b9-d18585e73461
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