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Fecha
2021-07-31
Derechos de acceso
info:eu-repo/semantics/openAccess
Título de la revista
ISSN de la revista
Título del volumen
Editorial
Elsevier
Citas
Resumen
Patients with Obsessive–Compulsive Disorder (OCD) present neuropsychological deficits across different cognitive domains, especially in executive functioning and information processing speed. Some studies have even suggested that speed deficits may underlie poor neuropsychological performance. However, this hypothesis remains unanswered in both OCD general population and OCD refractory subgroup. In addition, it is not clear whether such deficits are secondary to the clinical symptoms or may constitute a primary deficit. The aim of this study was to explore the speed of processing hypothesis in treatment-refractory OCD patients, and to clarify to what extent slowness is related to psychopathological symptoms. Both clinical and neuropsychological examination was conducted to assess 39 OCD refractory patients candidates for neurosurgery and 39 healthy matched individuals. Principal component analysis revealed a three-component structure in the neuropsychological battery being used, including a speed of processing, working memory, and conflict monitoring components. Group comparisons revealed that OCD patients performed significantly worse than healthy individuals in speed measures, but no differences were found in executive tests not influenced by time. Correlation analyses revealed a lack of association between neuropsychological and clinical measures. The results suggest that treatment-refractory OCD patients exhibit a primary deficit in information processing speed independent of clinical symptoms.
Descripción
This is an Accepted Manuscript of an article published by Elsevier in "Psychiatry research, 304, 2021, 114143", available at: https://doi.org/10.1016/j.psychres.2021.114143
Este es el manuscrito aceptado del artículo publicado por Elsevier en "Psychiatry research, 304, 2021, 114143", disponible en línea: https://doi.org/10.1016/j.psychres.2021.114143
Este es el manuscrito aceptado del artículo publicado por Elsevier en "Psychiatry research, 304, 2021, 114143", disponible en línea: https://doi.org/10.1016/j.psychres.2021.114143
Categorías UNESCO
Palabras clave
Attention, Clinical symptoms, Executive function, Information processing speed, Neuropsychology, Obsessive–compulsive disorder, Slowness
Citación
Vanesa Simón-Martínez, Garazi Laseca-Zaballa, Genny Lubrini, José A. Periáñez, Roberto Martínez Álvarez, Cristina V. Torres-Díaz, Nuria Martínez Moreno, Juan Álvarez-Linera, Marcos Ríos-Lago, Cognitive deficits and clinical symptoms in patients with treatment-refractory obsessive–compulsive disorder: The role of slowness in information processing, Psychiatry Research, Volume 304, 2021, 114143, https://doi.org/10.1016/j.psychres.2021.114143
Centro
Facultad de Psicología
Departamento
Psicología Básica II
Grupo de investigación
Grupo de Investigación en Neurociencia cognitiva y Neuroimagen (GINN)