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Pain-induced impulsivity is sexually dimorphic and mu-opioid receptor sensitive in rats

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dc.contributor.authorEspinoza Serrano, Nidia
dc.contributor.authorSaputra, Samuel G.
dc.contributor.authorCompany, Matthew
dc.contributor.authorNazarian, Arbi
dc.contributor.authorIbias Martín, Javier
dc.date.accessioned2024-05-20T11:50:37Z
dc.date.available2024-05-20T11:50:37Z
dc.date.issued2021-08-24
dc.description.abstractRationale and objectives Pain sensation can negatively impact cognitive function, including impulsivity. Pain-induced changes in impulsivity can contribute to development of psychiatric comorbidities found in those with chronic pain conditions. The goal of this study was to determine whether complete Freund’s adjuvant (CFA)-induced pain manipulation enhances impulsivity in rats. Whether the pain-induced impulsivity is sexually dimorphic, and if mu-opioid receptors play a role in these processes. Methods Male and female rats were screened for trait impulsivity and designated as high or low impulsive using a delay discounting task. Rats then received a hind paw injection of CFA, and their impulsivity was assessed for 16 days. The effects of morphine on impulsivity were also examined. In a separate experiment, rats were pretreated with beta-funaltrexamine (β-FNA) to determine the role of mu-opioid receptors on impulsivity. Results CFA treatment increased impulsivity in males and females. The onset of CFA-induced impulsivity was faster in high impulsive females than males. Morphine blocked CFA-induced impulsivity in both sexes in a dose- and time-dependent manner. β-FNA prevented the actions of morphine on CFA-induced impulsivity in high impulsive males, but not high impulsive females. Moreover, β-FNA increased CFA-induced impulsivity in morphine naïve males, but not females. Conclusion These findings demonstrate unique sex differences in CFA-induced impulsivity, response to morphine, and the impact of mu-opioid receptors. A better understanding of cognitive deficits and their mechanisms can provide insight into the development of substance abuse and psychiatric comorbidities that occur in people with chronic pain.en
dc.description.versionversión final
dc.identifier.doi10.1007/s00213-021-05963-z
dc.identifier.issn1432-2072
dc.identifier.urihttps://hdl.handle.net/20.500.14468/12623
dc.journal.titlePsychopharmacology
dc.journal.volume238
dc.language.isoen
dc.publisherSpringer Nature
dc.relation.centerFacultades y escuelas::Facultad de Psicología
dc.relation.departmentMetodología de las Ciencias del Comportamiento
dc.rightsAtribución-NoComercial-SinDerivadas 4.0 Internacional
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0
dc.subject.keywordsDelay discounting
dc.subject.keywordsOpioid
dc.subject.keywordsImpulsivity
dc.subject.keywordsPain
dc.subject.keywordsSex difference
dc.titlePain-induced impulsivity is sexually dimorphic and mu-opioid receptor sensitive in ratses
dc.typeartículoes
dc.typejournal articleen
dspace.entity.typePublication
person.familyNameIbias Martín
person.givenNameJavier
person.identifier.orcid0000-0002-4605-2450
relation.isAuthorOfPublication309c25b3-8ac4-4106-9ad3-4a441098fae9
relation.isAuthorOfPublication.latestForDiscovery309c25b3-8ac4-4106-9ad3-4a441098fae9
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