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2022-03-15
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info:eu-repo/semantics/openAccess
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Resumen
Stringent regulations and growing industrial interests have ensued the development of sustainable processes. Membrane assisted-nanoemulsification based on microengineered membranes has been explored for the sustainable production of therapeutic hydrophobic deep eutectic solvent (DES)-based nanoemulsions for enhanced antimicrobial applications. Hydrophobic DESs were synthesised by employing therapeutic terpenes: DL-menthol and thymol. To understand the mechanism of oil droplet detachment from the membrane when producing such nanoemulsions, the effect of hydrophilicity/hydrophobicity partition of the active membrane surface on the process performance was evaluated. Using a continuous phase cross-flow velocity of 0.32 m.s−1, a dispersed phase flowrate of 0.02 ml.min−1 and 2% (w/w) Tween 80 resulted in a DES-in-water nanoemulsion of 81.2 ± 0.9 nm droplet size. Novel observations like intrinsically reduced interfacial tension of 7.5 mN.m−1 between water and hydrophobic DES, and a hydrophobic DES wetting behaviour to both hydrophilic and hydrophobic active membrane surfaces were witnessed. Compared to DL-menthol, thymol or synthesised DES, the optimised DES-in-water nanoemulsions exhibited enhanced synergetic antimicrobial effect against Escherichia coli, Staphylococcus aureus and superior potency against Cutibacterium acnes, an acne inducing bacterial strain. These nanoemulsions were also cytocompatible with human keratinocytes and dermal fibroblasts. Lastly, membrane-assisted nanoemulsification manifested controlled size and monomodally distributed nanoemulsions compared to traditional ultrasound-driven emulsification.
Descripción
This is the accepted manuscript of the article. The registered version was first published in Separation and Purification Technology, 285 (2022), 120319, is available online at the publisher's website: https://doi.org/10.1016/j.seppur.2021.120319
Este es el manuscrito aceptado del artículo. La versión registrada fue publicada por primera vez en Separation and Purification Technology, 285 (2022), 120319, está disponible en línea en el sitio web del editor: https://doi.org/10.1016/j.seppur.2021.120319
The authors would like to acknowledge Executive Agency for Edu- cation, Audiovisual & Culture (EACEA) of the European Commission for the scholarship grant of Erasmus Mundus Doctorate in Membrane En- gineering (EUDIME) program to Syed Usman Taqui. Prof. Reyes Mallada and Dr. Ruth Lahoz from Nanoscience Institute of Aragon (INA), Uni- versity of Zaragoza are acknowledged for their unconditional support in fabrication and characterization of metallic membranes. This work is also supported by the Associate Laboratory for Green Chemistry - LAQV which is financed by national funds from FCT/MCTES (UIDB/50006/ 2020). Authors M.T.B. Crespo, F.B. Gaspar and I.C. Leonardo acknowl- edge the financial support from the project “MobFood – Mobilizing scientific and technological knowledge in response to the challenges of the agri-food market” (POCI-01-0247-FEDER-024524) financed by Eu- ropean Regional Development Fund (ERDF), through the Incentive System to Research and Technological development, within the Portugal2020 Competitiveness and Internationalization Operational Program; iNOVA4Health - UID/Multi/04462/2013, a program finan- cially supported by Fundaça˜o para a Ciˆencia e Tecnologia/Minist´erio da Educaça˜o e Ciˆencia, through national funds and co-funded by FEDER under the PT2020 Partnership Agreement; and INTERFACE Programme, through the Innovation, Technology and Circular Economy Fund (FITEC). This research was partially funded by the Spanish Ministry of Economy and Competitiveness (grant number CTQ2014-52384-R). V. Sebastian acknowledges the financial support from Ministerio de Cien- cia, Innovacio´n y Universidades, Programa Retos Investigacio´n, Proyecto REF: RTI2018-099019-A-I00. G. Mendoza gratefully ac- knowledges the support from the Miguel Servet Program (MS19/00092; Instituto de Salud Carlos III). CIBER-BBN is an initiative funded by the VI National R&D&i Plan 2008 -2011, Iniciativa Ingenio 2010, Consolider Program, CIBER Actions and financed by the Instituto de Salud Carlos III (Spain) with assistance from the European Regional Development Fund.
Este es el manuscrito aceptado del artículo. La versión registrada fue publicada por primera vez en Separation and Purification Technology, 285 (2022), 120319, está disponible en línea en el sitio web del editor: https://doi.org/10.1016/j.seppur.2021.120319
The authors would like to acknowledge Executive Agency for Edu- cation, Audiovisual & Culture (EACEA) of the European Commission for the scholarship grant of Erasmus Mundus Doctorate in Membrane En- gineering (EUDIME) program to Syed Usman Taqui. Prof. Reyes Mallada and Dr. Ruth Lahoz from Nanoscience Institute of Aragon (INA), Uni- versity of Zaragoza are acknowledged for their unconditional support in fabrication and characterization of metallic membranes. This work is also supported by the Associate Laboratory for Green Chemistry - LAQV which is financed by national funds from FCT/MCTES (UIDB/50006/ 2020). Authors M.T.B. Crespo, F.B. Gaspar and I.C. Leonardo acknowl- edge the financial support from the project “MobFood – Mobilizing scientific and technological knowledge in response to the challenges of the agri-food market” (POCI-01-0247-FEDER-024524) financed by Eu- ropean Regional Development Fund (ERDF), through the Incentive System to Research and Technological development, within the Portugal2020 Competitiveness and Internationalization Operational Program; iNOVA4Health - UID/Multi/04462/2013, a program finan- cially supported by Fundaça˜o para a Ciˆencia e Tecnologia/Minist´erio da Educaça˜o e Ciˆencia, through national funds and co-funded by FEDER under the PT2020 Partnership Agreement; and INTERFACE Programme, through the Innovation, Technology and Circular Economy Fund (FITEC). This research was partially funded by the Spanish Ministry of Economy and Competitiveness (grant number CTQ2014-52384-R). V. Sebastian acknowledges the financial support from Ministerio de Cien- cia, Innovacio´n y Universidades, Programa Retos Investigacio´n, Proyecto REF: RTI2018-099019-A-I00. G. Mendoza gratefully ac- knowledges the support from the Miguel Servet Program (MS19/00092; Instituto de Salud Carlos III). CIBER-BBN is an initiative funded by the VI National R&D&i Plan 2008 -2011, Iniciativa Ingenio 2010, Consolider Program, CIBER Actions and financed by the Instituto de Salud Carlos III (Spain) with assistance from the European Regional Development Fund.
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Palabras clave
Deep eutectic solvent (DES), DES-in-water nanoemulsions, Membrane emulsification, Ultrasound emulsification, Antibacterial activity
Citación
Syed, U. T., Leonardo, I. C., Mendoza, G., Gaspar, F. B., Gámez, E., Huertas, R. M., Crespo, M. T. B., Arruebo, M., Crespo, J. G., Sebastian, V., & Brazinha, C. (2022). On the role of components of therapeutic hydrophobic deep eutectic solvent-based nanoemulsions sustainably produced by membrane-assisted nanoemulsification for enhanced antimicrobial activity. Separation and Purification Technology, 285. https://doi.org/10.1016/J.SEPPUR.2021.120319
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Facultad de Ciencias
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Ciencias y Técnicas Fisicoquímicas