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Early androgen activity after birth determines the hypothalamic expression of androgen and estrogen receptors in adulthood in female but not in male rats

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dc.contributor.authorGarcía Úbeda, Rocío
dc.contributor.authorFernández García, José Manuel
dc.contributor.authorPrimo Chulvi, Ulises
dc.contributor.authorGrassi, Daniela
dc.contributor.authorBallesta, Antonio
dc.contributor.authorArévalo, María Ángeles
dc.contributor.authorCollado, Paloma
dc.contributor.authorPinos Sánchez, María Elena
dc.contributor.authorCarrillo Urbano, Beatriz
dc.contributor.funderMINISTERIO DE CIENCIA E INNOVACION (España)
dc.date.accessioned2025-12-05T09:50:01Z
dc.date.available2025-12-05T09:50:01Z
dc.date.issued2025-07-07
dc.descriptionThe registered version of this article, first published in “Reprod Biol Endocrinol. 2025 Jul 7;23(1):98", is available online at the publisher's website: BioMed Central,https://doi.org/10.1186/s12958-025-01430-y
dc.descriptionLa versión registrada de este artículo, publicado por primera vez en “Reprod Biol Endocrinol. 2025 Jul 7;23(1):98", está disponible en línea en el sitio web del editor: BioMed Central,https://doi.org/10.1186/s12958-025-01430-y
dc.description.abstractGonadal steroids are involved in the organization and programming of several neural systems. The main objective of this study was to determine whether androgen activity in the early postnatal stage influenced the long-term expression of androgen and estrogen receptors in the hypothalamus. Androgen receptors (AR) and the main metabolic pathways of testosterone were inhibited using Flutamide, an AR inhibitor, Letrozole, an aromatase inhibitor, or Finasteride, a 5-alpha-reductase inhibitor, during the first five days of life in male and female Wistar rats. Hypothalamic hormonal receptors AR, and estradiol receptors (ER)α, and ERβ were analyzed by qPCR, and circulating hormone levels (testosterone, DHT, and estradiol) were measured using ELISA assay at P90. The inhibition of AR, 5α-reductase or aromatase did not alter the hypothalamic levels of hormone receptors in males. However, in females, blocking the androgen receptor increased the ERβ, while the inhibition of 5α-reductase decreased the ERα and the inhibition of aromatase increased AR and ERβ hypothalamic mRNA levels. Moreover, testosterone plasma levels decreased significantly in females independent of whether the AR, 5α-reductase, or aromatase were inhibited. However, only the inhibition of aromatase decreased circulating testosterone levels in males. Furthermore, higher plasma testosterone and DHT levels were detected in males compared to females. Our results highlight the influence of androgen activity during the first days of life in females on the long-term expression of androgen and estrogen receptors in the hypothalamus, which reaffirms the importance of studying both sexes to accurately explain the processes that determine the programming of neural systems during development.en
dc.description.provenanceMade available in DSpace on 2025-12-05T09:50:01Z (GMT). No. of bitstreams: 1 Garcia-Ubeda et al2025_MARIA ELENA PINOS SA.pdf: 2055743 bytes, checksum: 8cf008e0e83343dcc6006b3306b0fafe (MD5) Previous issue date: 2025-07-07en
dc.description.sponsorshipMinisterio de Ciencia e innovación PID2020-115829GB-I00
dc.description.versionversión publicada
dc.identifier.citationGarcía-Úbeda R, Fernandez-Garcia JM, Primo U, Grassi D, Ballesta A, Arevalo MA, Collado P, Pinos H, Carrillo B. (2025). Early androgen activity after birth determines the hypothalamic expression of androgen and estrogen receptors in adulthood in female but not in male rats. Reprod Biol Endocrinol. 2025 Jul 7;23(1):98. doi: 10.1186/s12958-025-01430-y.
dc.identifier.doihttps://doi.org/10.1186/s12958-025-01430-y
dc.identifier.issn1477-7827
dc.identifier.urihttps://hdl.handle.net/20.500.14468/31026
dc.journal.issue1
dc.journal.titleReprod Biol Endocrinol
dc.journal.volume23
dc.language.isoen
dc.page.initial98
dc.publisherBioMed Central
dc.relation.centerFacultad de Psicología
dc.relation.departmentPsicobiología
dc.relation.projectidinfo:eu-repo/grantAgreement/MCIN/PID2020-115829GB-I00/ES/ Participación de los andrógenos en la programación de los circuitos neurohormonales que regulan la alimentación en ratas macho y hembra 2021-2025/NEUROFEED/
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.es
dc.subject3205.02 Endocrinología
dc.subject61 Psicología
dc.subject.keywordsAndrogen receptoren
dc.subject.keywordsAromataseen
dc.subject.keywords5α-reductaseen
dc.subject.keywordsGonadal steroidsen
dc.subject.keywordsDevelopmenten
dc.subject.keywordsSex differencesen
dc.subject.keywordsRaten
dc.titleEarly androgen activity after birth determines the hypothalamic expression of androgen and estrogen receptors in adulthood in female but not in male ratsen
dc.typeartículoes
dc.typejournal articleen
dspace.entity.typePublication
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