Persona:
Romero Hortelano, Miguel

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0000-0001-7923-8297
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Romero Hortelano
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Miguel
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2022 - 20232
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Mostrando 1 - 2 de 2
  • Miniatura
    Publicación
    Fractional Generalized Predictive Control Strategy With Fractional Constraints Handling
    (IEEE, 2022-12-08) Romero Hortelano, Miguel; Mañoso Hierro, María Carolina
    The control strategies based on the methodology known as Model–based Predictive Control (MPC) have been developed and widely adopted to control real plants. This is mainly due to their intrinsic ability to handle constrains and their capacity to predict and optimize the future behavior of the process using a dynamical model of the plant. On the other hand, the mathematical tool known as fractional calculus has been currently used for reformulating the predictive control strategies to reach a better performance adding new control parameters. This work extends the use of fractional operators for the constraints in one type of fractional predictive control strategy known as Fractional–order Generalized Predictive Control (FGPC), interpreting and discussing the results. In addition, a new method to soften constraints using fractional operator is proposed and illustrated with examples, even to adjust the final response of the system. A practical tuning of the rest of controller parameters with the help of a well–known mathematical software is also included to make use of the beneficial characteristics of this fractional predictive formulation.
  • Miniatura
    Publicación
    Maternal Supplementation with N-Acetylcysteine Modulates the Microbiota-Gut-Brain Axis in Offspring of the Poly I:C Rat Model of Schizophrenia.
    (MDPI, 2023-04-20) Casquero Veiga, M.; Fernández, J.; Lamanna Rama, N.; Gómez Rangel, Vanessa; Gálvez Robleño, Carlos; Villar, C. J.; Lombó, F.; Abalo, R.; Desco, Manuel; Soto Montenegro, M. L.; Romero Hortelano, Miguel; Santa Marta Pastrana, Cristina María
    The microbiota-gut-brain axis is a complex interconnected system altered in schizophrenia. The antioxidant N-acetylcysteine (NAC) has been proposed as an adjunctive therapy to antipsychotics in clinical trials, but its role in the microbiota-gut-brain axis has not been sufficiently explored. We aimed to describe the effect of NAC administration during pregnancy on the gut-brain axis in the offspring from the maternal immune stimulation (MIS) animal model of schizophrenia. Pregnant Wistar rats were treated with PolyI:C/Saline. Six groups of animals were studied according to the study factors: phenotype (Saline, MIS) and treatment (no NAC, NAC 7 days, NAC 21 days). Offspring were subjected to the novel object recognition test and were scanned using MRI. Caecum contents were used for metagenomics 16S rRNA sequencing. NAC treatment prevented hippocampal volume reduction and long-term memory deficits in MIS-offspring. In addition, MIS-animals showed lower bacterial richness, which was prevented by NAC. Moreover, NAC7/NAC21 treatments resulted in a reduction of proinflammatory taxons in MIS-animals and an increase in taxa known to produce anti-inflammatory metabolites. Early approaches, like this one, with anti-inflammatory/anti-oxidative compounds, especially in neurodevelopmental disorders with an inflammatory/oxidative basis, may be useful in modulating bacterial microbiota, hippocampal size, as well as hippocampal-based memory impairments.