Persona: María Hormigos, Roberto
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María Hormigos
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Publicación Preclinical Validation of an Electrochemical Sensor for Alcohol Consumption Monitoring in a Polydrug Self-Administration Animal Model(MDPI, 2025-03-08) Garrido Matilla, Lucía; María Hormigos, Roberto; Monago Maraña, Olga; Marcos, Alberto; Ambrosio Flores, Emilio; González Crevillén, AgustínAn electrochemical sensor for identification and monitoring of alcoholism was preclinically validated by analyzing plasma from polydrug-consuming rats (alcohol and cocaine). The sensor measures by adsorptive transfer square wave voltammetry the glycosylation level of transferrin, which is an alcoholism biomarker, through a recently reported parameter called the electrochemical index of glycosylation (EIG). Three rat groups were designed: saline group, cocaine group, and cocaine–alcohol group. Moreover, two periods of withdrawal were studied, after 2 days and 30 days. The alcohol–cocaine group after 2 days of withdrawal showed significantly lower EIG values (p < 0.1) than the rest of groups and also alcohol–cocaine group after 30 days of withdrawal, so the sensor was able to identify the alcohol consumption in rats and to monitor the recovery of glycosylation level after 30 days of withdrawal, even combined with cocaine. Furthermore, the effect of sex was also considered. Receiver operating characteristic (ROC) curves were developed for each sex and the corresponding cut-off values were determined. The sensor showed a clinical sensitivity of 70% for male and 75% for female, and a specificity of 67% for both sexes. This preclinical validation demonstrated the possibilities of this sensor for point of care testing of alcoholism, even in cocaine addicts, making it a potential tool for diagnosis and monitoring of alcohol consumption in detox treatments for humans.Publicación Wearable sensor for solar ultraviolet A radiation monitoring based on a basic bismuth nitrate / graphene quantum dots composite(Elsevier, 2025-11-26) María Hormigos, Roberto; Monago Maraña, Olga; Zapardiel Palenzuela, Antonio; González Crevillén, Agustín; Universidad Nacional de Educación a Distancia (UNED)/SantanderUltraviolet A (UV-A) radiation from the Sun is a significant risk factor for skin cancer owing to long-term exposition for outdoor workers. The growing need for wearable health monitoring devices demands real-time UV-A sensors with high analytical performance to avoid skin conditions resulting from prolonged UV-A exposure. In this work, we aimed to develop a novel, power-less, low-cost, long-term-stable, and flexible wearable sensor. Such a sensor is based on basic bismuth nitrate (BBN) covered with graphene quantum dots (GQDs) as a photodetector. BBN@GQD photoelectrical material was produced by a very low-cost pyrolytic procedure in gram-scale quantities on a simple hot plate. GQDs improved photoelectrical activity of BBN, yielding good responsivity of 0.25 mA·W−1 (at 0 V bias, incident light intensity 17 μW·cm−2 and 365 nm wavelength). The combination of BBN@GQD and ITO electrodes provided a very sensitive and selective photodetector (a limit of detection of 1.6 ± 0.6 μW·cm−2 light intensity at 0 V bias for 365 nm UV-A wavelength), better than most current UV-A photodetectors. Its high sensitivity at 0 V bias enables its employment as a functional power-free real-time UV-A monitor device. Moreover, the wearable sensor showed acceptable reproducibility (18.9 % relative standard deviation at 12.5 μW·cm−2 light intensity) and long-term stability (up to 1 month of storage). This work proposes a promising wearable device for UV-A monitoring in an outdoor environment, using a new photosensitive material (BBN@GQD), which offers new opportunities in the development of UV photodetectors.