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Alcohol consumption and preference in female rats induced by reward downshift reveals sex generality of the modulatory role of physical activity

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dc.contributor.authorCastejón, Elena
dc.contributor.authorAmbrosio Flores, Emilio
dc.contributor.authorPellón Suárez de Puga, Ricardo
dc.contributor.authorTorres, Carmen
dc.date.accessioned2026-01-19T13:25:47Z
dc.date.available2026-01-19T13:25:47Z
dc.date.issued2025-04-01
dc.descriptionThis is an Accepted Manuscript of an article published by Lippincott, Williams & Wilkinsin "Behavioural Pharmacology, 36(2-3) (2025), 144-155", available at: https://doi.org/10.1097/FBP.0000000000000799
dc.descriptionEste es el manuscrito aceptado del artículo publicado por Lippincott, Williams & Wilkinsin en "Behavioural Pharmacology, 36(2-3) (2025), 144-155", disponible en línea: https://doi.org/10.1097/FBP.0000000000000799
dc.description.abstractIncreased voluntary consumption of alcohol has been demonstrated in male rats exposed to frustrative reward downshift (the emotional self-medication effect). Access to a wheel for voluntary running abolished this effect in male rats, suggesting an attenuating effect of physical exercise on the negative affect induced by reward downshift and its consequences on drug intake. The present study analyzed this effect in female rats. Sixty-four food-deprived female Wistar rats received 32% sucrose [4% (Experiment 1) or 2% (Experiment 2) in controls] during 10, 5-min preshift sessions followed by 4% (Experiment 1) or 2% (Experiment 2) sucrose during 5 postshift sessions. Immediately after each consummatory session, animals were exposed to a 2-h, two-bottle preference test involving 32% alcohol vs. water. Half of the animals also had access to a running wheel during the preference test. The results showed (a) lower sucrose consumption in the downshifted groups (32–4% and 32–2%) compared to the unshifted controls (4–4% and 2–2%, respectively); (b) higher alcohol preference in downshifted groups without access to a wheel compared with downshifted groups with access to the wheel (Experiments 1 and 2); and (c) increased alcohol intake (g/kg) after experiencing reward downshift in animals without access to the wheel (Experiment 1). Voluntary wheel running thus reduced alcohol intake in female rats experiencing reward downshift. These findings are comparable to previous results reported in male rats and support the usefulness of physical exercise to prevent alcohol self-medication induced by frustrative nonreward.en
dc.description.provenanceMade available in DSpace on 2026-01-19T13:25:47Z (GMT). No. of bitstreams: 1 Alcohol consumption and preference in female rats induced by reward downshift reveals sex generality of the modulatory role of physical activity. Ricardo Pellón Suárez de Puga.pdf: 887466 bytes, checksum: a3c0a80ca8c330f03dca2f59a4854145 (MD5) Previous issue date: 2025-04-01en
dc.description.versionversión final
dc.identifier.citationCastejón, E., Ambrosio, E., Pellón, R., y Torres, C. (2025). «Alcohol consumption and preference in female rats induced by reward downshift reveals sex generality of the modulatory role of physical activity». Behavioural Pharmacology, 36(2-3), 144-155. https://doi.org/10.1097/FBP.0000000000000799
dc.identifier.doihttps://doi.org/10.1097/FBP.0000000000000799
dc.identifier.eissn1473-5849
dc.identifier.issn0955-8810
dc.identifier.urihttps://hdl.handle.net/20.500.14468/31460
dc.journal.issue2-3
dc.journal.titleBehavioural Pharmacology
dc.journal.volume36
dc.language.isoen
dc.page.final155
dc.page.initial144
dc.publisherLippincott, Williams & Wilkins
dc.relation.centerFacultad de Psicología
dc.relation.departmentPsicología Básica I
dc.relation.researchgroupAnálisis experimental de la Conducta
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject6106 Psicología experimental
dc.subject.keywordsAlcohol consumptionen
dc.subject.keywordsEmotional self-medicationen
dc.subject.keywordsFemale ratsen
dc.subject.keywordsFrustrationen
dc.subject.keywordsPhysical activityen
dc.subject.keywordsReward downshifen
dc.subject.keywordsWheel runningen
dc.titleAlcohol consumption and preference in female rats induced by reward downshift reveals sex generality of the modulatory role of physical activityen
dc.typeartículoes
dc.typejournal articleen
dspace.entity.typePublication
relation.isAuthorOfPublicationddd20842-ce7c-4040-b326-f8c8f245bd14
relation.isAuthorOfPublication8edbde84-9307-47aa-9ef8-5e85de175df6
relation.isAuthorOfPublication.latestForDiscoveryddd20842-ce7c-4040-b326-f8c8f245bd14
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