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Fecha
2025-07-09
Derechos de acceso
info:eu-repo/semantics/openAccess
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Editorial
Springer
Citas
Resumen
Background
The reliability of the recommended echocardiographic methods for assessing RV diastolic function has been questioned. We aimed to validate noninvasive indices of RV diastolic function, derived from tricuspid Doppler and myocardial deformation metrics, against intrinsic diastolic chamber properties and filling pressures.
Methods
We obtained simultaneous high-fidelity pressure-volume loops and echocardiographic data in separate animal and clinical settings: (1) a porcine model of acute hemodynamic interventions (n = 13), and (2) patients with Fallot tetralogy and pulmonary hypertension (n = 9). These designs allow for within- and between-subject validation. From the PV loops data, we obtained the reference values of RV stiffness (S+), elastic recoil (S−) and relaxation (τ) constants, as well as the contribution of passive properties to instantaneous diastolic pressures.
Results
In the animal setting, only the tricuspid E/A ratio and e’ velocity weakly correlated with S+ (Rrm:0.36 and 0.28 respectively, p < 0.01 for both). In the clinical group, no correlation was found between the echocardiographic indices and the intrinsic diastolic properties. Isovolumic relaxation time and early diastolic global strain-rate (GSR) correlated with mean right atrial pressure (RAP) (Spearman r: -0.73 and 0.85, respectively, p < 0.05 for both). E/e’ and E/GSR ratio were not associated with RAP. Tricuspid e’ and GSR negatively correlated with passive pressure component (only due to) at valve opening (Rrm -0.27 and − 0.33, respectively, p < 0.01 for both).
Conclusions
Recommended echocardiographic indices of RV diastolic function do not reflect intrinsic RV diastolic properties. Therefore, the application of these indices for inferring RV diastolic function and filling pressures is limited.
Descripción
The registered version of this article, first published in “Cardiovascular Ultrasound, 23(15)", is available online at the publisher's website: https://doi.org/10.1186/S12947-025-00351-5
La versión registrada de este artículo, publicado por primera vez en “Cardiovascular Ultrasound, 23(15)", está disponible en línea en el sitio web del editor: https://doi.org/10.1186/S12947-025-00351-5
La versión registrada de este artículo, publicado por primera vez en “Cardiovascular Ultrasound, 23(15)", está disponible en línea en el sitio web del editor: https://doi.org/10.1186/S12947-025-00351-5
Categorías UNESCO
Palabras clave
Diastolic function, Right ventricle, Elastic recoil, Relaxation, Stiffness, Echocardiography
Citación
Pérez del Villar, C., Prieto-Arévalo, R., García-Carreño, J., Martínez-Legazpi, P., Rodríguez-Pérez, D., Benito, Y., Delgado-Montero, A., Antoranz, J. C., Desco, M. M., Herrera Flores, C., Corisco Beltrán, R., Fernández-Avilés, F., & Bermejo, J. (2025). Validation of noninvasive indices of right ventricular diastolic function. Simultaneous echocardiography and pressure-volume catheterization studies. Cardiovascular Ultrasound, 23(15). https://doi.org/10.1186/S12947-025-00351-5
Centro
Facultad de Ciencias
Departamento
Física Matemática y de Fluídos