dc.contributor.author	Roura Martínez, David
dc.contributor.author	Ucha Tortuero, Marcos
dc.contributor.author	Moreno Fernández, Mario
dc.contributor.author	Alberto Castillo, Carlos
dc.contributor.author	Ballesteros Yánez, Inmaculada
dc.contributor.author	Marcos, Alberto
dc.contributor.author	Ambrosio Flores, Emilio
dc.contributor.author	Higuera Matas, Alejandro
dc.contributor.funder	Agencia Estatal de Investigación (AEI)
dc.date.accessioned	2026-04-20T10:40:14Z
dc.date.available	2026-04-20T10:40:14Z
dc.date.issued	2026-04-16
dc.description	This is the postprint of an article published by Elsevier in "Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2026", available online: https://doi.org/10.1016/j.pnpbp.2026.111688
dc.description	Este es el manuscrito aceptado de un artículo publicado por Elsevier en "Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2026", disponible en línea: https://doi.org/10.1016/j.pnpbp.2026.111688
dc.description.abstract	Stress is known to play a critical role in relapse to drug use as well as in food craving. Craving itself is a key determinant of relapse, and cue-induced drug craving has been shown to increase, or ‘incubate’, over time for certain drugs such as cocaine and nicotine, though this effect is less consistent for others such as opiates. However, the modulations of stress-related biochemical systems after early or protracted withdrawal that could contribute to this incubation phenomenon have not yet been systematically examined in animal models, nor has the specificity of these mechanisms been tested across different drug classes or reinforcers. To address this gap, we analysed brains from male Lewis rats that self-administered cocaine (0.75 mg/kg, i.v.), heroin (0.075 mg/kg, i.v.), or saline, and subsequently assessed changes in plasma corticosterone, ornithine and other stress-related amines, alongside central gene and protein expression CRH, CRH2 receptor, and α- and β-adrenergic receptor subunits -Adra1, Adra2a and Adrb1) in cortico-striato-amygdalar nodes (after 1 or 30 days of withdrawal). A parallel experiment was conducted using sucrose as a reinforcer. Our findings indicate that although most effects were reinforcer-specific, convergent adaptations were also observed, particularly within noradrenergic systems and the basolateral amygdala, expanding our knowledge about the neurochemical rearrangements occurring during withdrawal.	en
dc.description.provenance	Made available in DSpace on 2026-04-20T10:40:14Z (GMT). No. of bitstreams: 1 HigueraMatas_Alejandro_NAandCRHeffectsofwithd_ALEJANDRO HIGUERA MA.pdf: 2082231 bytes, checksum: a8122d80b9d6f8cfcf922f41ce61b64b (MD5) Previous issue date: 2026-04-16	en
dc.description.version	versión final
dc.identifier.citation	David Roura-Martínez, Marcos Ucha, Mario Moreno-Fernández, Carlos Alberto Castillo, Inmaculada Ballesteros-Yánez, Alberto Marcos, Emilio Ambrosio, Alejandro Higuera-Matas, Shared and reinforcer-specific alterations in the CRH and noradrenergic systems following short- and long-term withdrawal from cocaine, heroin, and sucrose self-administration, Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2026, 111688, ISSN 0278-5846, https://doi.org/10.1016/j.pnpbp.2026.111688
dc.identifier.doi	https://doi.org/10.1016/j.pnpbp.2026.111688
dc.identifier.eissn	1878-4216
dc.identifier.issn	0278-5846
dc.identifier.uri	https://hdl.handle.net/20.500.14468/32380
dc.journal.title	Progress in Neuro-Psychopharmacology and Biological Psychiatry
dc.language.iso	en
dc.page.initial	111688
dc.publisher	ELSEVIER
dc.relation.center	Facultad de Psicología
dc.relation.department	Psicobiología
dc.relation.projectid	info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/ PID2022-142469OA-I00/ES/RECONSOLIDACION DE MEMORIAS ASOCIADAS A AUTOADMINISTRACION DE HEROINA Y SU IMPLICACION EN PREVENCION DE RECAIDAS: POSIBLE USO TERAPEUTICO DE LA VIA MTOR
dc.relation.projectid	info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/ PID2023-146922OB-I00/ES/PROCESOS PSICOBIOLOGICOS IMPLICADOS EN LA ABSTINENCIA DEL POLICONSUMO DE COCAINA Y ALCOLHOL
dc.relation.projectid	info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/ PID2023-149142OB-I00/ES/ESTUDIO DE LA IMPLICACION DE LA MICROGLIA EN LA ADICCION A COCAINA Y EXPLORACION DE NUEVAS ESTRATEGIAS TERAPEUTICAS ASOCIADAS
dc.rights	info:eu-repo/semantics/openAccess
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject	61 Psicología
dc.subject.keywords	Noradrenalide	en
dc.subject.keywords	Corticotropin-releasing-factor	en
dc.subject.keywords	incubation of seeking	en
dc.subject.keywords	basolateral amydala	en
dc.subject.keywords	Withdrawal	en
dc.subject.ods	ODS 3 - Salud y bienestar
dc.title	Shared and reinforcer-specific alterations in the CRH and noradrenergic systems following short- and long-term withdrawal from cocaine, heroin, and sucrose self-administration	en
dc.type	artículo	es
dc.type	journal article	en
dspace.entity.type	Publication
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Publicación: Shared and reinforcer-specific alterations in the CRH and noradrenergic systems following short- and long-term withdrawal from cocaine, heroin, and sucrose self-administration

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Shared and reinforcer-specific alterations in the CRH and noradrenergic systems following short- and long-term withdrawal from cocaine, heroin, and sucrose self-administration