Persona:
Lubrini, Genny

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Dirección de correo electrónico
glubrini@psi.uned.es
ORCID
0000-0001-8526-6198
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Lubrini
Nombre de pila
Genny
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2021 - 20242
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Mostrando 1 - 2 de 2
  • Miniatura
    Publicación
    New functional dissociations between prefrontal and parietal cortex during task switching: A combined fMRI and TMS study
    (Elsevier, 2024-10) Periáñez, José A.; Viejo Sobera, Raquel; Lubrini, Genny; Álvarez Linera, Juan; Rodríguez Toscano, Elisa; Moreno, María D.; Arango, Celso; Redolar Ripoll, Diego; Muñoz Marrón, Elena; Ríos Lago, Marcos
    Preparatory control in task-switching has been suggested to rely upon a set of distributed regions within a frontoparietal network, with frontal and parietal cortical areas cooperating to implement switch-specific preparation processes. Although recent causal evidence using transcranial magnetic stimulation (TMS) have generally supported this model, alternative results from both functional neuroimaging and neurophysiological studies have questioned the switch-specific role of both frontal and parietal cortices. The aim of the present study was to clarify the involvement of prefrontal and parietal areas in preparatory cognitive control. With this purpose, an fMRI study was conducted to identify the brain areas activated during cue events in a task-switching paradigm, indicating whether to switch or to repeat among numerical tasks. Then, TMS was applied over the specific coordinates previously identified through fMRI, that is, the right inferior frontal gyrus (IFG) and right intraparietal sulcus (IPS). Results revealed that TMS over the right IFG disrupted performance in both switch and repeat trails in terms of delayed responses as compared to Sham condition. In contrast, TMS over the right IPS selectively interfered performance in switch trials. These findings support a multi-component model of executive control with the IFG being involved in more general switch-unspecific process such as the episodic retrieval of goals, and the IPS being related to the implementation of switch-specific preparation mechanisms for activating stimulus-response mappings. The results are discussed within the framework of contemporary hierarchical models of prefrontal cortex organization, suggesting that distinct prefrontal areas may carry out coordinated functions in preparatory control.
  • Miniatura
    Publicación
    Cognitive deficits and clinical symptoms in patients with treatment-refractory obsessive–compulsive disorder: The role of slowness in information processing
    (Elsevier, 2021-07-31) Simón-Martínez, Vanesa; Laseca-Zaballa, Garazi; Lubrini, Genny; Albarrán Periáñez, José David; Martínez Álvarez, Roberto; Torres-Díaz, Cristina V.; Martínez Moreno, Nuria; Álvarez-Linera, Juan; Ríos Lago, Marcos; Fundación Tatiana Pérez de Guzmán el Bueno
    Patients with Obsessive–Compulsive Disorder (OCD) present neuropsychological deficits across different cognitive domains, especially in executive functioning and information processing speed. Some studies have even suggested that speed deficits may underlie poor neuropsychological performance. However, this hypothesis remains unanswered in both OCD general population and OCD refractory subgroup. In addition, it is not clear whether such deficits are secondary to the clinical symptoms or may constitute a primary deficit. The aim of this study was to explore the speed of processing hypothesis in treatment-refractory OCD patients, and to clarify to what extent slowness is related to psychopathological symptoms. Both clinical and neuropsychological examination was conducted to assess 39 OCD refractory patients candidates for neurosurgery and 39 healthy matched individuals. Principal component analysis revealed a three-component structure in the neuropsychological battery being used, including a speed of processing, working memory, and conflict monitoring components. Group comparisons revealed that OCD patients performed significantly worse than healthy individuals in speed measures, but no differences were found in executive tests not influenced by time. Correlation analyses revealed a lack of association between neuropsychological and clinical measures. The results suggest that treatment-refractory OCD patients exhibit a primary deficit in information processing speed independent of clinical symptoms.